SIGMA CHEMICAL CO -- L-ISOLEUCINE, I2752  -- 6505-00N092469
<pre>=====================  Product Identification  =====================

Product ID:L-ISOLEUCINE, I2752
MSDS Date:07/01/1999
FSC:6505
NIIN:00N092469
Status Code:A
=== Responsible Party ===
Company Name:SIGMA CHEMICAL CO
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Info Phone Num:314-771-5765
Emergency Phone Num:314-771-5765
CAGE:21076
=== Contractor Identification ===
Company Name:SIGMA CHEMICAL COMPANY
Address:3050 SPRUCE ST
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Phone:314-771-5765
CAGE:21076

=============  Composition/Information on Ingredients  =============

Ingred Name:L-ISOLEUCINE
CAS:73-32-5
RTECS #:NR4705000
Code:F
Other REC Limits:N/K 
OSHA PEL:N/K 
OSHA STEL:N/K 
ACGIH TLV:N/K 
ACGIH STEL:N/K 

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:SEE TOXICOLOGICAL INFORMATION.
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE HARMFUL BY INHALATION,
    INGESTION, OR SKIN ABSORPTION. MAY CAUSE EYE IRRITATION. MAY CAUSE
    SKIN IRRITATION. MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND
    UPPER RESPIRATORY TRACT. TO  THE BEST OF MANUFACTURER'S KNOWLEDGE,
    THE CHEMICAL, PHYSICAL, AND TOXICOLOGICAL PROPERTIES HAVE NOT BEEN
    THOROUGHLY INVESTIGATED. ADDITIONAL INFORMATION: THE LEVOROTARY (L)
    FORMS OF LEUCINE, ISOLEUCIN E AND VALINE HAVE BEEN FOUND TO HAVE
    TUMOR-PROMOTING ACTIVITY FOR BLADDER CARCINOMAS. SCIENCE 231, 843,
    21 FEBRUARY 1986.
Effects of Overexposure:SEE HEALTH HAZARDS.

=======================  First Aid Measures  =======================

First Aid:EYES/SKIN: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER
    FOR AT LEAST 15 MINUTES, WHILE REMOVING CONTAMINATED CLOTHING AND
    SHOES. INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING, GIVE
    ARTIFICIAL R ESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
    INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
    CALL A PHYSICIAN. DISCARD CONTAMINATED CLOTHING AND SHOES.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:NON-COMBUSTIBLE. USE EXTINGUISHING MEDIA
    APPROPRIATE TO SURROUNDING FIRE CONDITIONS.
Fire Fighting Procedures:WEAR NIOSH APPROVED SELF-CONTAINED BREATHING
    APPARATUS AND FULL PROTECTIVE EQUIPMENT .
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR NIOSH APPROVED RESPIRATOR, CHEMICAL
    SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SPILLED
    MATERIAL SHOULD BE CAREFULLY WIPED UP OR MOISTENED WITH WATER AND
    REMOVED. VENTILATE AREA AND WAS H SPILL SITE AFTER MATERIAL PICKUP
    IS COMPLETE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:AVOID INHALATION. AVOID CONTACT WITH
    EYES, SKIN AND CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. KEEP
    TIGHTLY CLOSED. STORE IN A COOL DRY PLACE.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:MECHANICAL EXHAUST REQUIRED.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:EYEWASH AND DELUGE SHOWER MEETING ANSI
    DESIGN CRITERIA . WEAR OTHER PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health

==================  Physical/Chemical Properties  ==================

Melt/Freeze Pt:=288.C, 550.4F
Appearance and Odor:WHITE POWDER.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZING AGENTS.
Hazardous Decomposition Products:TOXIC FUMES OF CARBON MONOXIDE, CARBON
    DIOXIDE, NITROGEN OXIDES.

===================  Toxicological Information	===================

Toxicological Information:RTECS NUMBER: NR4705000 - ISOLEUCINE, L-.
    TOXICITY DATA: IPR-RAT LD50: 6822 MG/KG; ABBIA4 58, 253, 1955. ONLY
    SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS)
    DATA IS PRESENTED HERE.  SEE ACTUAL ENTRY IN RTECS FOR COMPLETE
    INFORMATION.

=====================  Ecological Information  =====================

Ecological:DATA NOT YET AVAILABLE.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
    SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
    AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
    ENVIRONMENTAL REGULATIONS.

===================  MSDS Transport Information  ===================

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
    INFORMATION.

=====================  Regulatory Information  =====================

Federal Regulatory Information:REVIEWS, STANDARDS, AND REGULATIONS:
    OEL=MAK. OEL-RUSSIA: STEL 5 MG/M3 JAN 1993. NOHS 1974: HZD 81864;
    NIS 1; TNF 53; NOS 3; TNE 750. NOES 1983: HZD 81864; NIS 3; TNF
    740; NOS 13; TNE 18202; TFE 13865 . EPA TSCA SECTION 8 (B) CHEMICAL
    INVENTORY.
State Regulatory Information:

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